问一下ki67和细胞分化之间的关系
我母亲三年前的切片今年拿出来看了一下，病理的医生说是低分化，三年之前的报告没有写，说细胞都没有腺管。我问一下没有腺管的细胞是不是就是所谓的增殖细胞。从而ki67的值很高。这两个是一码事么？
我妈3年之前发现的时候1.5x1.5x1，但是有5年没体检，偶然发现的。当时没有淋巴结转移，其他地方也没有转移。手术切除以后三年。CEA慢慢在提升，其他的复发我看都是1-2年就复发的，我妈这个3年多了，虽然CEA在缓慢提升，但是没有任何体征，CT，B超，脑部，骨扫描都是正常的。
所以我就想，是不是低分化也并不意味着增值速度快？或者手术切除+化疗以后散落在身体里的癌细胞变乖了？ The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is widely used in routine pathological investigation as a proliferation marker.
简单的说，Ki67 是细胞增生的一个指标，Ki高说明是低分化，增长快，预后不好。但需结合其它临床指标判断分析。
Clinically, pKi67 has been shown to correlate with metastasis and the clinical stage of tumors. In addition, it has been shown that Ki67 expression is significantly higher malignant tissues with poorly differentiated tumor cells, as compared with normal tissue. According to its predictive role, pKi67 expression identifies subpopulations of patients who are more likely to respond to a given therapy. The Ki67 labeling index is an independent prognostic factor for survival rate, which includes all stages and grade categories. There is a correlation between the ratio of Ki67‑positive malignant cells and patient survival. It has been shown that blocking of Ki67 either by microinjection of antibodies or through the use of antisense oligonucleotides leads to the arrest of cell proliferation. Specifically, antisense oligonucleotides and antibodies against pKi67 have been shown to inhibit the progression of the cell cycle. The Ki67 protein is well characterized at the molecular level and is extensively used as a prognostic and predictive marker for cancer diagnosis and treatment. 另外是不是低分化的绝大多数都是tp53有突变的 低分化，意味着免疫组化里面的P53是阳性的，同时P53阳性也意味着TP53基因的缺失
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