发给老马备查:
k$ S3 M4 }. Y4 @. ], I滴水察海(69304838) 15:23:23
. ?7 w9 |' G5 u: E. v老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱$ h, _$ U6 s$ d/ X, v& P, r) j$ z
吉非替尼和S-1连用的依据
$ y# |* Z4 h4 ?; ?4 ], J9 cGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
- R# c4 \! p- C' [* d7 M是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
S- ?% I; ]$ A! @这样是不是推理出,耐药后,可以用S-1和培美了?' ~& T3 Z9 O$ E$ @7 B
结论:9 c( X8 X |1 \
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |